hereditary nonpolyposis colorectal cancer in northeastern iran
نویسندگان
چکیده
background: there are no data on familial aggregation of colorectal cancer (crc) in northeastern iran. the aim of this study was to determine the prevalence of early-onset crc and patients suspected for hereditary non-polyposis colorectal cancer (hnpcc) based on the clinical criteria in this area. materials and methods: documents were collected from two hospitals in mashhad regarding 326 inpatients during 2013-2015. demographics, clinical, and tumor-related features were recorded. interviews were done to identify cancer in the family up to second-degree relatives. results: 326 patients with crc (48.5% male) were evaluated. the mean age at diagnosis was 55.44±14.85 years, with 91 patients (27.9%) below 45 years old. eleven (3.4%) patients fulfilled the amsterdam ii criteria and 136 (41.7%) patients met at least one criterion of the revised bethesda guideline. there was no difference between early- and late-onset crc regarding the frequency of crc in 1 st degree relatives or tumor site ( p =0.73, p =0.64). however, crc in second-degree relatives and cases suspected for hnpcc were more common in early-onset of the disease ( p =0.022, p =0.024). the patients who fulfilled the amsterdam ii criteria had lower mean age and higher frequency of proximal cancer ( p =0.03, p =0.048). conclusion: as crc is common in the young population and crc clustering and patients suspected for hnpcc are also frequently encountered, measures should be taken to crc screening policy and genetic studies in this area.
منابع مشابه
Hereditary nonpolyposis colorectal cancer.
Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, is the most common form of hereditary colorectal cancer (CRC). A well-orchestrated cancer family history is essential for its diagnosis since, unlike its familial adenomatous polyposis (FAP) hereditary cancer counterpart, HNPCC lacks distinguishing clinical stigmata of its cancer genetic risk. Discoveries in the 1990s of germ...
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*Corresponding author: Ladan Goshayeshi. Department of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: [email protected] Tel: 985138012753 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons. org/licenses/by/3.0), which permits unrestricted use, di...
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normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : there is a lack of data on familial aggregation of colorectal cancer (crc) in iran. we aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (hnpcc) and familial colorectal cancer (fcc) and to determine the frequency of extracolonic cancers in these families in isfahan. methods : we rev...
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عنوان ژورنال:
گوارشجلد ۲۱، شماره ۲، صفحات ۱۲۶-۰
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